4-甲氧基-2-硝基乙酰苯胺合成路线 （共 48 条）
反应条件
sodium sulfide 6 h; Heating;
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
(i) NO<HSO4>, NaOAc, (ii) /BRN= 969212/; Multistep reaction;
参考文献
Smith,P.A.S.; Hall,J.H.
Journal of the American Chemical Society, 1962 , vol. 84, p. 480 - 485
反应条件
1: glacial acetic acid; nitric acid / <10 2: concentrated sulfuric acid / 110 °C 3: ethyl nitrite View Scheme
参考文献
Meldola; Eyre
Journal of the Chemical Society, 1902 , vol. 81, p. 993
参考文献
Nishino et al.
Yuki Gosei Kagaku Kyokaishi, 1959 , vol. 17, p. 166,169
Chem.Abstr., 1959 , p. 11280
反应条件
1: Raney nickel / Hydrogenation
2: aqueous ethanol; sodium acetate
View Scheme
参考文献
Elderfield et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1589
反应条件
1: 472 mg / LiAlH4 / tetrahydrofuran / 1 h
2: 33.6 percent / 2.5 h / Heating
View Scheme
参考文献
Tanaka; Ino; Murakami
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 7 p. 1876 - 1886
反应条件
1: H2 / 5percent Pd/C
2: 59.1 percent / dimethylformamide / 89 h / Ambient temperature
3: 63.6 percent / Raney Ni / ethyl acetate / 0.83 h / Heating
View Scheme
参考文献
Tanaka, Kenjiro; Shimazaki, Michiko; Murakami, Yasuoki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 8 p. 2714 - 2722
反应条件
1.1: hydrogenchloride / water / Reflux
2.1: diethyl ether / 1 h / 100 °C
2.2: 3 h / 50 - 110 °C
2.3: 3 h / 50 - 110 °C
3.1: hydrogenchloride; trifluoroacetic acid; sodium nitrite / water / 1 h / 20 °C
4.1: trichlorophosphate / 3 h / Reflux
5.1: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
phosphorus pentoxide; xylene
参考文献
Dewar
Journal of the Chemical Society, 1944 , p. 619,622
反应条件
1: glacial acetic acid; nitric acid / <10
2: concentrated sulfuric acid / 110 °C
View Scheme
参考文献
Meldola; Eyre
Journal of the Chemical Society, 1902 , vol. 81, p. 993
