2-氨基-4-氟-苯甲酰胺合成路线 （共 10 条）
反应条件
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in methanol; N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
WO2010/99379 A1, ;
Page/Page column 135 ;
反应条件
ammonia in 1,4-dioxane; water T=100°C; 20 h;
参考文献
US2008/293749 A1, ;
Page/Page column 13 ;
反应条件
DIEA; benzotriazol-1-ol in N,N-dimethyl-formamide
参考文献
US2012/53176 A1, ;
US 20120053176 A1
反应条件
ammonia; triethylamine in tetrahydrofuran; water 2.5 h;
参考文献
Synthesis (Germany), , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
hydrogen; platinum(IV) oxide in methanol Ambient temperature;
参考文献
Chemical and pharmaceutical bulletin, , vol. 36, # 8 p. 2955 - 2967
反应条件
1: SOCl2 / benzene / 3.5 h / Heating 2: 64.3 percent / 28percent aq. NH3 / H2O 3: 100 percent / hydrogen / PtO2 / methanol / Ambient temperature View Scheme
参考文献
Chemical and pharmaceutical bulletin, , vol. 36, # 8 p. 2955 - 2967
反应条件
1: 64.3 percent / 28percent aq. NH3 / H2O 2: 100 percent / hydrogen / PtO2 / methanol / Ambient temperature View Scheme
参考文献
Chemical and pharmaceutical bulletin, , vol. 36, # 8 p. 2955 - 2967
反应条件
phosphorus pentoxide in toluene Dehydration; 15 h; Heating;
参考文献
Rampa, Angela; Bisi, Alessandra; Belluti, Federica; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Cavrini, Vanni; Cavalli, Andrea; Recanatini, Maurizio
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 497 - 506
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / 20 °C 2: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Cheng, Ran; Guo, Tianjian; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
9 h; Heating / reflux;
2: With water in tetrahydrofuran
参考文献
Gruenenthal GmbH
Patent: US2008/293749 A1, 2008 ;
Location in patent: Page/Page column 13 ;
