1-溴-4-(2-甲氧基丙烷-2-基)苯合成路线 （共 5 条）
反应条件
sodium hydride in tetrahydrofuran T=20°C; 24 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/48727 A1, 2006 ;
Location in patent: Page/Page column 82 ;
WO 2006/048727 A1
反应条件
sodium hydride in tetrahydrofuran T=20°C; 24 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2005/90300 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
WO 2005/090300 A1
反应条件
pyridine 21 h; Ambient temperature;
参考文献
Creary, Xavier; Aldridge, Timothy
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4280 - 4285
反应条件
1: conc. HCl / CH2Cl2 / 5 h / Ambient temperature 2: 96 percent / pyridine / 21 h / Ambient temperature View Scheme
参考文献
Creary, Xavier; Aldridge, Timothy
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4280 - 4285
反应条件
Ledwith–Weitz salt in dichloromethane T=-20.1°C; ΔH(excit), ΔS(excit); Thermodynamic data;
参考文献
Maslak, Przemyslaw; Asel, Stacey L.
Journal of the American Chemical Society, 1988 , vol. 110, # 24 p. 8260 - 8261
