hydrogenchloride in di-isopropyl ether; water T=22°C; 72 h;
参考文献
GILEAD SCIENCES, INC.; RAY, Adrian S.; WATKINS, William J.; LINK, John O.; OLDACH, David W.; DELANEY, IV, William E.
Patent: WO2013/40492 A2, 2013 ;
Location in patent: Page/Page column 102 ;
1: β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=20°C; 0.583333 h; 2: (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester in tetrahydrofuran T=20°C; optical yield given as percent de;
参考文献
Journal of Organic Chemistry, , vol. 76, # 20 p. 8311 - 8319
1.1: dichloromethane / 1.25 h / 0 °C 2.1: di-isopropyl ether / -10 °C / Resolution of racemate 3.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / 21 h / 20 - 50 °C 3.2: 60.25 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 20 p. 8311 - 8319
1.1: triethylamine / dichloromethane / 0.83 h / -78 °C 2.1: dichloromethane / 1.25 h / 0 °C 3.1: di-isopropyl ether / -10 °C / Resolution of racemate 4.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / 21 h / 20 - 50 °C 4.2: 60.25 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 20 p. 8311 - 8319
