6-氯-5-氟-7-氮杂吲哚合成路线 （共 2 条）
反应条件
1: With methyl chloroformate; 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran T=5°C; 3 h; 2: With sodium hydroxide in tetrahydrofuran T=10°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=7;
参考文献
ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm
Patent: WO2012/74769 A1, 2012 ;
Location in patent: Page/Page column 32 ;
WO 2012/074769 A1
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / diethyl ether / 3.08 h / Inert atmosphere 2.1: 1,1,1,3,3,3-hexamethyl-disilazane; methyl chloroformate / tetrahydrofuran / 3 h / 5 °C 2.2: 2 h / 10 °C 2.3: pH 7 View Scheme
参考文献
ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm
Patent: WO2012/74769 A1, 2012 ;
WO 2012/074769 A1
