1-氮杂双环[2.2.1]庚烷-4-羧酸乙酯合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=40°C; P=760 Torr;
参考文献
Orlek; Wadsworth; Wyman; King
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1245 - 1246
反应条件
1: 1.) LDA, N,N,N1,N1-tetramethylethylenediamine (TMEDA) / 1.) Et2O, hexane, -65 deg C, 0.25 h, 2.) Et2O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min 2: HBr (gas) / 84 h / Ambient temperature 3: aq. K2CO3 / 0.17 h 4: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr View Scheme
参考文献
Orlek; Wadsworth; Wyman; King
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1245 - 1246
反应条件
1: HBr (gas) / 84 h / Ambient temperature 2: aq. K2CO3 / 0.17 h 3: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr View Scheme
参考文献
Orlek; Wadsworth; Wyman; King
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1245 - 1246
反应条件
1: aq. HCl / 17 h / Heating 2: SOCl2 / 4.25 h / Heating 3: ammonia / CH2Cl2 / -40 - 20 °C 4: 82 percent / TFAA, pyridine / tetrahydrofuran / 0.25 h View Scheme
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: 6 M HCl / 10 h / Heating
2: SOCl2 / 4.5 h / Heating
View Scheme
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
1: aq. HCl / 17 h / Heating
2: SOCl2 / 4.25 h / Heating
3: ammonia / CH2Cl2 / -40 - 20 °C
View Scheme
参考文献
CoMentis, Inc.
Patent: US2009/88418 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090088418 A1
