1-氮杂双环[2.2.1]庚烷-4-甲酰胺合成路线 （共 4 条）
反应条件
pyridine; trifluoroacetic anhydride in tetrahydrofuran 0.25 h;
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: aq. HCl / 17 h / Heating
2: SOCl2 / 4.25 h / Heating
3: ammonia / CH2Cl2 / -40 - 20 °C
View Scheme
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
ammonia in dichloromethane
T=-40 - 20°C; Yield given;
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: SOCl2 / 4.25 h / Heating
2: ammonia / CH2Cl2 / -40 - 20 °C
View Scheme
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
