1-氮杂双环[2.2.1]庚烷-4-甲酰氯合成路线 （共 4 条）
反应条件
1: 1.) HBr gas, 2.) aq. K2CO3, 3.) H2 / 3.) 10percent Pd/C
2: 5 N HCl / 17 h / Heating
3: SOCl2 / 4 h / Heating
View Scheme
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: 1.) LDA, N,N,N1,N1-tetramethylethylenediamine (TMEDA) / 1.) Et2O, hexane, -65 deg C, 0.25 h, 2.) Et2O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min
2: HBr (gas) / 84 h / Ambient temperature
3: aq. K2CO3 / 0.17 h
4: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr
5: 6 M HCl / 10 h / Heating
6: SOCl2 / 4.5 h / Heating
View Scheme
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
1: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr
2: 6 M HCl / 10 h / Heating
3: SOCl2 / 4.5 h / Heating
View Scheme
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
1: 6 M HCl / 10 h / Heating
2: SOCl2 / 4.5 h / Heating
View Scheme
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
