(S)-2-(4-(2-氯苯氧基)-2-氧代-2,5-二氢-1H-吡咯-1-基)-4-甲基戊酸甲酯合成路线 （共 2 条）
反应条件
1: (L)-leucine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine in acetonitrile T=25 - 105°C; 2: (E)-4-bromo-3-(2-chloro-phenoxy)-but-2-enoic acid ethyl ester in acetonitrile T=105°C; Product distribution / selectivity;
参考文献
Berthel, Steven Joseph; Brinkman, John A.; Hayden, Stuart; Haynes, Nancy-Ellen; Kester, Robert Francis; McDermott, Lee Apostle; Qian, Yimin; Sarabu, Ramakanth; Scott, Nathan Robert; Tilley, Jefferson Wright
Patent: US2009/264445 A1, 2009 ;
Location in patent: Page/Page column 57 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=25°C; 1 h; 2: With hydrogenchloride in water Product distribution / selectivity;
参考文献
Berthel, Steven Joseph; Brinkman, John A.; Hayden, Stuart; Haynes, Nancy-Ellen; Kester, Robert Francis; McDermott, Lee Apostle; Qian, Yimin; Sarabu, Ramakanth; Scott, Nathan Robert; Tilley, Jefferson Wright
Patent: US2009/264445 A1, 2009 ;
Location in patent: Page/Page column 57 ;
