sodium methylate in diethyl ether T=0°C;

sodium hydroxide in methanol T=20°C; 1 h;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1- hydroxybenzotriazole / dichloromethane / 0.5 h / 0 &deg;C / |Inert atmosphere<br />1.2: 12 h / 0 - 23 &deg;C / |Inert atmosphere<br />2.1: CuDPP / DMFA / 24 h / 80 &deg;C / |Inert atmosphere<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=25&deg;C;&nbsp;12&nbsp;h;&nbsp;&nbsp;Green chemistry;&nbsp;<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=40&deg;C;&nbsp;24&nbsp;h;&nbsp;<br /> &nbsp;