6-(1-哌嗪基)-3-吡啶胺合成路线 （共 4 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethanol; ethyl acetate T=70°C; P=750.075 Torr; 0.5 h; H-Cube.(TM).;
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
反应条件
1: 84.6 percent / acetonitrile / 2.5 h / 20 °C 2: H2 / Pd/C / tetrahydrofuran / 20 °C / 760 Torr View Scheme
参考文献
Cui, Yingjie; Dang, Yaxian; Yang, Yushe; Zhang, Shuhua; Ji, Ruyun
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 2 p. 209 - 214
反应条件
1.1: potassium carbonate / water / 0.25 h / 150 °C / Microwave irradiation 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.2: 20 °C 3.1: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM). View Scheme
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
反应条件
1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere 1.2: 20 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM). View Scheme
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
