4-(5-氨基吡啶-2-基)哌嗪-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
hydrogen; nickel in tetrahydrofuran P=2585.81 Torr; 5 h;
参考文献
WARNER-LAMBERT COMPANY, LLC
Patent: US2005/182078 A1, 2005 ;
Location in patent: Page/Page column 9; 12 ;
US 20050182078 A1
反应条件
1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 2585.81 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 7 p. 2433 - 2446
反应条件
1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 2585.81 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 7 p. 2433 - 2446
参考文献
US2011/224137 A1, ;
US 20110224137 A1
反应条件
1: sodium carbonate 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 16 p. 4779 - 4783
反应条件
1: potassium carbonate / water / 0.25 h / 150 °C / Microwave irradiation 2: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM). View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 45 p. 5905 - 5909
