1: 100 percent / p-TSA / methanol / 20 °C 2: 68 percent / NaH; 1,3-diaminopropane / 70 °C 3: 69 percent / PDC / dimethylformamide 4: Cu(OAc)2 / pyridine / 0.17 h / Heating 5: H2 / 10 percent Pd/C / CHCl3 / 20 °C 6: aq. NaOH / tetrahydrofuran / 20 °C 7: oxalyl chloride / CH2Cl2 / 12 h / 20 °C View Scheme

1: 100 percent / p-TSA / methanol / 20 °C 2: 68 percent / NaH; 1,3-diaminopropane / 70 °C 3: 69 percent / PDC / dimethylformamide View Scheme

1: 100 percent / p-TSA / methanol / 20 °C 2: 68 percent / NaH; 1,3-diaminopropane / 70 °C View Scheme