1: With 10 palladium on activated charcoal; hydrogen in isopropyl alcohol T=55°C; P=1875.19 Torr; Inert atmosphereLarge scale reaction; 2: With hydrogen; acetic acid in isopropyl alcohol T=55°C; P=1875.19 Torr; 10 h; Large scale reaction; 3: With sodium hydroxide in water pH=12; Large scale reaction;

1: With hydrogen; acetic acid in ethanol T=20°C; 18 h; 2: With sodium hydroxide in tert-butyl methyl ether; water

lithium aluminium tetrahydride in tetrahydrofuran 1) 15 min, reflux, 2) 24 h, RT;

1.1: thionyl chloride / 5 h / Heating 2.1: 1,2-dimethoxy-ethane / 15 h / Heating 2.2: 8 h / 200 °C 3.1: 80 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating 4.1: 54 percent / hydrogen / Pd/C / methanol / 20 °C View Scheme

1.1: 1,2-dimethoxy-ethane / 15 h / Heating 1.2: 8 h / 200 °C 2.1: 80 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating 3.1: 54 percent / hydrogen / Pd/C / methanol / 20 °C View Scheme

1: 80 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating 2: 54 percent / hydrogen / Pd/C / methanol / 20 °C View Scheme

in diethyl ether T=0°C;

formic acid T=100°C; 2 h;