3-甲基-2-环己烯-1-酮合成路线 （共 314 条）
反应条件
copper(I) iodide-lithium chloride in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Reetz, Manfred T.; Kindler, Alois
Journal of Organometallic Chemistry, 1995 , vol. 502, # 1-2 p. C5 - C7
反应条件
1: methyllithium With copper(l) iodide in tetrahydrofuran T=-78 - 20°C; 2: 3-methyl-cyclohex-2-en-1-one With boron trifluoride diethyl etherate in tetrahydrofuran T=20°C; 2.5 h;
参考文献
Billings, Susan B.; Woerpel
Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5171 - 5178
反应条件
chloro-trimethyl-silane; copper(I) bromide in tetrahydrofuran T=0°C; 1 h;
参考文献
Westermann, Juergen; Nickisch, Klaus
Angewandte Chemie, 1993 , vol. 105, # 9 p. 1429 - 1431
反应条件
copper(l) chloride in tetrahydrofuran T=0°C; 4 h;
参考文献
Cahiez, Gerard; Alami, Mouad
Tetrahedron Letters, 1989 , vol. 30, # 27 p. 3541 - 3544
反应条件
1: methyl iodide With magnesium in diethyl ether 2: 3-methyl-cyclohex-2-en-1-one With copper(l) iodide in diethyl ether T=-30 - 20°C; 2 h; Further stages.;
参考文献
Srikrishna; Beeraiah
Synthetic Communications, 2007 , vol. 37, # 17 p. 2855 - 2860
反应条件
1: (E)-dimethyl(4-methoxy-styryl)aluminum With copper(I) thiophene-2-carboxylate; 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine in diethyl ether T=-30°C; 0.25 h; Inert atmosphere; 2: 3-methyl-cyclohex-2-en-1-one in diethyl ether T=-30°C; 14 h; Inert atmosphere; enantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 19, # 45 p. 15226 - 15239
反应条件
in tetrahydrofuran; diethyl ether T=-78°C; 1.25 h;
参考文献
Lipshutz, Bruce H.; Ellsworth, Edmund L.; Siahaan, Teruna J.
Journal of the American Chemical Society, 1989 , vol. 111, # 4 p. 1351 - 1358
反应条件
1: C10H13Al With copper(I) thiophene-2-carboxylate; 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine in diethyl ether T=-30°C; 0.25 h; Inert atmosphere; 2: 3-methyl-cyclohex-2-en-1-one in diethyl ether T=-30°C; 14 h; Inert atmosphere; enantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 19, # 45 p. 15226 - 15239
反应条件
1: C5H11Al With copper(I) thiophene-2-carboxylate; 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine in diethyl ether T=-30°C; 0.25 h; Inert atmosphere; 2: 3-methyl-cyclohex-2-en-1-one in diethyl ether T=-30°C; 14 h; Inert atmosphere; enantioselective reaction;
参考文献
Mueller, Daniel; Alexakis, Alexandre
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15226 - 15239
反应条件
1: C6H13Al With copper(I) thiophene-2-carboxylate; 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine in diethyl ether T=-30°C; 0.25 h; Inert atmosphere; 2: 3-methyl-cyclohex-2-en-1-one in diethyl ether T=-30°C; 14 h; Inert atmosphere; enantioselective reaction;
参考文献
Mueller, Daniel; Alexakis, Alexandre
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15226 - 15239
