3-甲基-2-环己烯-1-酮合成路线 （共 314 条）
反应条件
(i) AllMgBr, Et2O, THF, (ii) /BRN= 1560601/; Multistep reaction;
参考文献
Leyendecker,F. et al.
Tetrahedron Letters, 1977 , p. 1591 - 1594
反应条件
1: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 20-60 min, 2.) THF, hexane, -78 deg C, 1 h 2: 12 percent / iodine / 1.5 h / Heating View Scheme
参考文献
Mphahlele, Malose J.; Pienaar, Andre; Modro, Tomasz A.
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 7, p. 1455 - 1460
参考文献
Knoevenagel
Justus Liebigs Annalen der Chemie, 1897 , vol. 297, p. 193 Anm.
Full Text Show Details
Knoevenagel; Klages
Justus Liebigs Annalen der Chemie, 1894 , vol. 281, p. 103
反应条件
potassium tert-butylate; hydrogen; trans-RuCl2[(S)-TolBINAP][(R)-IPBAN] in isopropyl alcohol; tert-butyl alcohol T=25°C; P=6840 Torr; 8 h; Title compound not separated from byproducts;
参考文献
SOLVIAS AG
Patent: WO2007/104690 A1, 2007 ;
Location in patent: Page/Page column 27 ;
反应条件
sodium dithionite; sodium hydrogencarbonate; methyl trialkyl(C8-C10)ammonium chlorides in water; benzene 2 h; Heating;
参考文献
Tetrahedron, , vol. 42, # 16 p. 4603 - 4610
反应条件
lithium aluminium tetrahydride; 4,7,13,18-tetraoxa-1,10-diazabicyclo[8.5.5]eicosane in tetrahydrofuran 0.25 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Loupy, Andre; Seyden-Penne, Jacqueline
Tetrahedron, 1980 , vol. 36, p. 1937 - 1942
反应条件
hydrogen; HRuCl(TBPC)2 in benzene T=80°C; P=30400 Torr; 22 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Massonneau, Viviane; Maux, Paul Le; Simonneaux, Gerard
Journal of Organometallic Chemistry, 1987 , vol. 327, p. 269 - 274
反应条件
(R)-DTBM-Segphos; [Cu(PPh3)2NO3]; hydrogen; sodium t-butanolate in isopropyl alcohol T=30°C; P=37503.8 Torr; 18 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shimizu, Hideo; Nagano, Takuto; Sayo, Noboru; Saito, Takao; Ohshima, Takashi; Mashima, Kazushi
Synlett, 2009 , # 19 p. 3143 - 3146
反应条件
potassium tri-sec-butyl-borohydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Synthetic Communications, , vol. 18, # 1 p. 89 - 96
反应条件
ethanol; sodium of Knoevenagel as 'trans-form' designated substance;
参考文献
Skita; Ritter
Chemische Berichte, 1911 , vol. 44, p. 673
