4,6-二氯嘧啶合成路线

Porter, John R; Archibald, Sarah C; Brown, Julien A; Childs, Kirstie; Critchley, David; Head, John C; Hutchinson, Brian; Parton, Ted A H; Robinson, Martyn K; Shock, Anthony; Warrellow, Graham J; Zomaya, Alex
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 12 p. 1595 - 1598

1193-21-14,6-二氯嘧啶

1450-88-06-巯基-4(1H)-嘧啶硫酮

参考文献

US5684011 A1, ;

1193-21-14,6-二氯嘧啶+

75-64-9叔丁胺

945896-38-84-叔丁基氨基-6-氯嘧啶

参考文献

MEDIZINISCHE UNIVERSITAET WIEN; TECHNISCHE UNIVERSITAET WIEN
Patent: US2012/294835 A1, 2012 ;
Location in patent: Page/Page column 16 ;

1193-21-14,6-二氯嘧啶+

57260-71-61-Boc-哌嗪

479691-42-44-(4-氯-嘧啶-2-基)-哌嗪-1-羧酸叔丁酯

参考文献

WO2009/145360 A1, ;

Page/Page column 116 ;
WO 2009/145360 A1

1193-21-14,6-二氯嘧啶+

87120-72-71-Boc-4-氨基哌啶

939986-76-24-(6-氯-嘧啶-4-基氨基)-哌啶-1-羧酸叔丁酯

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; TRAN, Joe, A.; CHEN, Chen
Patent: WO2010/149685 A1, 2010 ;
Location in patent: Page/Page column 49 ;
WO 2010/149685 A1

1193-21-14,6-二氯嘧啶

36847-10-64,6-二溴嘧啶

参考文献

Schomaker; Delia
Journal of Organic Chemistry, 2001 , vol. 66, # 21 p. 7125 - 7128

123-75-1四氢吡咯+

1193-21-14,6-二氯嘧啶

939986-64-84-氯-6-(吡咯啉-1-基)嘧啶

参考文献

van der Westhuyzen, Christiaan W.; Rousseau, Amanda L.; Parkinson, Christopher J.
Tetrahedron, 2007 , vol. 63, # 25 p. 5394 - 5405