4,6-二氯嘧啶合成路线

Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 12 ;
US 20040087601 A1

1193-21-14,6-二氯嘧啶+

128796-39-44-三氟甲基苯硼酸

659729-09-64-氯-6-(4-(三氟甲基)苯基)嘧啶

参考文献

Norman, Mark H.; Zhu, Jiawang; Fotsch, Christopher; Bo, Yunxin; Chen, Ning; Chakrabarti, Partha; Doherty, Elizabeth M.; Gavva, Narender R.; Nishimura, Nobuko; Nixey, Thomas; Ognyanov, Vassil I.; Rzasa, Robert M.; Stec, Markian; Surapaneni, Sekhar; Tamir, Rami; Viswanadhan, Vellarkad N.; Treanor, James J. S.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3497 - 3514

1193-21-14,6-二氯嘧啶+

128796-39-44-三氟甲基苯硼酸

659729-09-64-氯-6-(4-(三氟甲基)苯基)嘧啶+

697739-37-0

参考文献

Merck Sharp and Dohme Limited
Patent: WO2004/46133 A1, 2004 ;
Location in patent: Page 40 ;
WO 2004/046133 A1