反应条件
1: 80 percent / conc. HCl / 0.02 h / Heating
2: 1.) TMEDA, n-BuLi / 1.) hexanes, a.) -78 deg C, 60 min b.) RT, 1.5h; 2.) RT 3h.
3: diisobutylammonium hydride / CH2Cl2; hexane / 3 h / -78 °C
4: 75 percent / triethylamine, DMAP / CH2Cl2 / 0.5 h / 0 °C
5: 1.) LDA / 1.) hexane, THF, -78 deg C, 10 min, 2.) reflux, 2h
6: 1.) LDA / 1.) hexane, THF, -78 deg C, 10 min, 2.) reflux, 2h
7: 5percent aq. NaOH
8: diethyl ether / 0.5 h / 0 °C
View Scheme
参考文献
Kurth, Mark J.; Beard, Richard L.
Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 4085 - 4088
