2-甲基-1,3-环己二酮合成路线 （共 134 条）
反应条件
1: 1,4-diazabicyclooctane (DABCO) / 1,2-dimethoxy-ethane / 12 h / Ambient temperature
2: triethylamine, benzoic acid / xylene / 24 h / Heating
View Scheme
参考文献
Darvesh; Grant; MaGee; Valenta
Canadian Journal of Chemistry, 1991 , vol. 69, # 4 p. 712 - 722
反应条件
1: With aluminum oxide
T=20°C; Michael addition; 0.166667 h;
2: With pyrrolidine
Robinson annulation; 0.116667 h; microwave irradiation;
参考文献
Takatori, Kazuhiko; Nakayama, Masayasu; Futaishi, Naoko; Yamada, Saori; Hirayama, Shinobu; Kajiwara, Masahiro
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 4 p. 455 - 457
反应条件
1: With triethylamine in tetrahydrofuran
Heating;
2: With L-phenylalanine; (1S)-10-camphorsulfonic acid in N,N-dimethyl-formamide
参考文献
Assefa, Haregewein; Nimrod, Alison; Walker, Larry; Sindelar, Robert
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1619 - 1623
反应条件
1: triethylamine / ethyl acetate
2: C9H14O5S; L-phenylalanine / N,N-dimethyl-formamide
View Scheme
参考文献
REATA PHARMACEUTICALS, INC.; ANDERSON, Eric; BOLTON, Gary, L.; CAPRATHE, Bradley; JIANG, Xin; LEE, Chitase; ROARK, William, H.; VISNICK, Melean
Patent: WO2012/83306 A2, 2012 ;
反应条件
3 A molecular sieve; toluene-4-sulfonic acid in 1,4-dioxane
Heating;
参考文献
Murae, Tatsushi; Sasaki, Makoto; Konosu, Toshiyuki; Matsuo, Hisaaki; Takahashi, Takeyoshi
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3411 - 3414
反应条件
potassium ethanolate
参考文献
Stetter; Klauke
Chemische Berichte, 1953 , vol. 86, p. 513,517
反应条件
potassium tert-butylate in tert-butyl alcohol
T=60°C; 96 h;
参考文献
Laverde Jr., Antonio; Da Conceicao, Gelson J. A.; Queiroz, Sonia C. N.; Fujiwara, Fred Y.; Marsaioli, Anita J.
Magnetic Resonance in Chemistry, 2002 , vol. 40, # 7 p. 433 - 442
反应条件
1: 96 percent / TsOH / benzene / Heating
2: 88 percent / KH / tetrahydrofuran / -78 °C
3: 68 percent / O3 / CH2Cl2 / -78 °C
View Scheme
参考文献
Demir, Ayhan S.; Enders, Dieter
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 6 p. 553 - 563
反应条件
sodium hydride
1.) THF, 2.) destill. 0.013 kPa; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Garst, Michael E.; McBride, Bill J.
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1362 - 1364
反应条件
in acetonitrile
T=25°C; 1 h; pH=7; other pH; Product distributionRate constant;
参考文献
Winkler; Finck-Estes
Tetrahedron Letters, 1989 , vol. 30, # 52 p. 7293 - 7296
