1: 96 percent / CuI; Et3N / Pd(PPh3)2Cl2 / 4 h / 20 °C 2: 79 percent / KF / dimethylformamide / 4 h / 20 °C 3: 60 percent / α-chymotrypsin; aq. NH4OAc / dimethylformamide / 12 h / 20 °C 4: 79 percent / 10percent TFA / CH2Cl2 / 1 h / 20 °C View Scheme

sodium hydroxide in acetone 2 h; Ambient temperature;

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / aq. NaOH / tetrahydrofuran<br />2: 92 percent / toluene; methanol<br /> <br /> &nbsp;