1-(4-溴苯基)环丁胺盐酸盐合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate in dichloromethane; water
参考文献
WO2012/7416 A1, ;
Page/Page column 75 ;
WO 2012/007416 A1
反应条件
1.1: sodium hydrogencarbonate / dichloromethane; water 1.2: 20 °C / Inert atmosphere 2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 3 h / Reflux View Scheme
参考文献
WO2012/7345 A2, ;
WO 2012/007345 A2
反应条件
1: 1-(4-bromophenyl)cyclobutanamine hydrochloride With sodium hydrogencarbonate in dichloromethane; water 2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; BÄRFACKER, Lars; SCOTT, William; HÄGEBARTH, Andreas; REHWINKEL, Hartmut; POLITZ, Oliver; NEUHAUS, Roland; BÖMER, Ulf
Patent: WO2013/104611 A1, 2013 ;
Location in patent: Page/Page column 47 ;
反应条件
1: sodium hydrogencarbonate / dichloromethane; water 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; INCE, Stuart; REHWINKEL, Hartmut; HAEGEBARTH, Andrea; POLITZ, Oliver; NEUHAUS, Roland; BOeMER, Ulf
Patent: WO2012/7416 A1, 2012 ;
WO 2012/007416 A1
Title/Abstract Full Text Show Details
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SCOTT, William; HAeGEBARTH, Andrea; INCE, Stuart; REHWINKEL, Hartmut; POLITZ, Oliver; NEUHAUS, Roland; BRIEM, Hans; BOeMER, Ulf
Patent: WO2012/136776 A1, 2012 ;
WO 2012/136776 A1
