sodium hydroxide in 1,4-dioxane; water 2 h; Ambient temperature;

1: 100 percent / hydrogen / Pd/C / methanol; CH2Cl2 / 48 h / 40 °C 2: 90 percent / HCl; acetic acid / H2O / 24 h / Heating 3: 86 percent / NaOH / H2O; dioxane / 39 h View Scheme

1: 76 percent / benzene / 1 h / 50 - 55 °C 2: 95 percent / sodium methoxide / methanol / 0.5 h / 20 °C 3: 100 percent / hydrogen / Pd/C / methanol; CH2Cl2 / 48 h / 40 °C 4: 90 percent / HCl; acetic acid / H2O / 24 h / Heating 5: 86 percent / NaOH / H2O; dioxane / 39 h View Scheme

1: 95 percent / sodium methoxide / methanol / 0.5 h / 20 °C 2: 100 percent / hydrogen / Pd/C / methanol; CH2Cl2 / 48 h / 40 °C 3: 90 percent / HCl; acetic acid / H2O / 24 h / Heating 4: 86 percent / NaOH / H2O; dioxane / 39 h View Scheme

1: 82 percent / 20percent aq. HCl / 30 h / Heating 2: 90 percent / NaOH / dioxane; H2O / 2 h / Ambient temperature View Scheme

1: 58 percent / t-BuOK / 2-methyl-propan-2-ol / 24 h / 20 °C 2: 82 percent / 20percent aq. HCl / 30 h / Heating 3: 90 percent / NaOH / dioxane; H2O / 2 h / Ambient temperature View Scheme

1: 90 percent / HCl; acetic acid / H2O / 24 h / Heating 2: 86 percent / NaOH / H2O; dioxane / 39 h View Scheme