4-氯-2-氯甲基吡啶盐酸盐合成路线 (共 3 条)
反应条件
thionyl chloride in chloroform 2 h; Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1188755 A1, 2002 ;
Location in patent: Page 53 ;
参考文献
EP1188755 A1, ;
Page 53 ;
反应条件
lithium hydroxide; trilithium phosphorothioate in water; N,N-dimethyl-formamide 2 h;
参考文献
Barnes, John H.; Fatome, Marc; Jones, Christopher E. L.; Murray, Stephen G.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 211 - 216