1: With sodium sulfide in N,N-dimethyl-formamide T=20°C; 36 h; Inert atmosphere; 2: With hydrogenchloride; zinc in water Cooling with iceInert atmosphere;
potassium carbonate in N,N-dimethyl-formamide T=150 - 160°C; 3 h;
参考文献
Li, Bing; Pai, Ramdas; Cardinale, Steven C.; Butler, Michelle M.; Peet, Norton P.; Moir, Donald T.; Bavari, Sina; Bowlin, Terry L.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2264 - 2276