1: With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane in diethyl ether; hexane T=0 - 40°C; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; hexane; water T=0 - 40°C; 3: With sodium hydroxide in diethyl ether; hexane; water pH=~ 11;
参考文献
Dr. Reddy's Laboratories Ltd.
Patent: US2010/144731 A1, 2010 ;
Location in patent: Page/Page column 24-25 ;
1: dimethylsulfoxide / 2 h / 120 °C 2: LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269
