Lee, Jin-Kyun; Fuchter, Matthew J.; Williamson, Rachel M.; Leeke, Gary A.; Bush, Edward J.; McConvey, Ian F.; Saubern, Simon; Ryan, John H.; Holmes, Andrew B.
Chemical Communications, 2008 , # 39 p. 4780 - 4782
potassium carbonate in dimethyl sulfoxide
T=90°C; 8 h;
参考文献
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Patent: WO2005/7625 A2, 2005 ;
Location in patent: Page 63-64 ;
1: 87 percent / K2CO3 / dimethylsulfoxide / 8 h / 90 °C
2: Red-Al / tetrahydrofuran; toluene / 3 h / 0 °C
3: 1.96 g / Et3N / tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269
1: 89 percent / K2CO3 / dimethylsulfoxide / 8 h / 90 °C
2: H2; LiOH / Raney-Ni; Pd/C / ethyl acetate
3: Et3N / CH2Cl2 / 6 h / 20 °C
4: aq. HCl / tetrahydrofuran / 1 h / 0 - 20 °C
View Scheme
参考文献
Tangallapally, Rajendra P.; Lee, Robin E.B.; Lenaerts, Anne J.M.; Lee, Richard E.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2584 - 2589
