2-氨基-6-氯-4-羟基嘧啶合成路线 （共 8 条）
反应条件
sodium hydroxide 1 h; Heating;
参考文献
Burgdorf, Lars T; Carell, Thomas
Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 1 p. 293 - 301
反应条件
acetic acid in sodium hydroxide
参考文献
Hoffmann-La Roche Inc.
Patent: US4939252 A1, 1990 ;
反应条件
trichlorophosphate T=100 - 110°C; 6 h;
参考文献
Aoyagi; Yanada; Bessho; Yoneda; Armarego
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1537 - 1539
反应条件
hydrogenchloride; water
参考文献
Journal of the Chemical Society, , p. 1497,1499
反应条件
sulfuric acid; nitric acid T=0°C; 0.0833333 h;
参考文献
Burgdorf, Lars T; Carell, Thomas
Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 1 p. 293 - 301
参考文献
Michael; Cottam; Smee; Robins; Kini
Journal of medicinal chemistry, 1993 , vol. 36, # 22 p. 3431 - 3436
反应条件
tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate in acetonitrile T=110°C; 0.333333 h;
参考文献
Savall, Brad M.; Chavez, Frank; Tays, Kevin; Dunford, Paul J.; Cowden, Jeffery M.; Hack, Michael D.; Wolin, Ronald L.; Thurmond, Robin L.; Edwards, James P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2429 - 2439
参考文献
Aoyagi; Yanada; Bessho; Yoneda; Armarego
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1537 - 1539
