2-甲基-4,6-二羟基嘧啶合成路线 （共 21 条）
反应条件
sodium ethanolate in ethanol
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
反应条件
sulfuric acid; nitric acid T=5 - 10°C;
参考文献
Astrat'ev; Dashko; Mershin; Stepanov; Urazgil'deev
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 5 p. 729 - 733
反应条件
1: With sulfuric acid; nitric acid in water T=4 - 40°C; 2 h; 2: With water 1 h; 3: With potassium hydroxide in diethyl ether; ethanol
参考文献
Totalfuersvarets Forskningsinstitut
Patent: US6340780 B1, 2002 ;
Location in patent: Example 3 ;
反应条件
1: 64 percent / POCl3 / 5 h / Heating 2: 48 percent / Pd(PPh3)2Cl2 / dimethylformamide / 20 h / 110 °C View Scheme
参考文献
Hanan, Garry S.; Schubert, Ulrich S.; Volkmer, Dirk; Riviere, Emmanuel; Lehn, Jean-Marie; Kyritsakas, Nathalie; Fischer, Jean
Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 169 - 182
反应条件
trichlorophosphate T=10 - 120°C; 11 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2471793 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
1: chloroform / 18 - 55 °C 2: trichlorophosphate; N,N-dimethyl-aniline / water / 20 h / 120 °C / Cooling with ice View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BIRCH, Alan, Martin; GOLDBERG, Frederick, Woolf; LEACH, Andrew
Patent: WO2011/121350 A1, 2011 ;
WO 2011/121350 A1
反应条件
1: With sulfuric acid; nitric acid in water T=4 - 40°C; 2 h; 2: With water 1 h; 3: With potassium hydroxide in diethyl ether; ethanol
参考文献
Totalfuersvarets Forskningsinstitut
Patent: US6340780 B1, 2002 ;
Location in patent: Example 3 ;
反应条件
1: 68 percent / TFA; 90percent aq. HNO3 / 12 h / 20 °C 2: 49 percent / POCl3; diisopropylethylamine / toluene / 3 h / Heating View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
trichlorophosphate Heating;
参考文献
Farard, Julien; Loge, Cedric; Pfeiffer, Bruno; Lesur, Brigitte; Duflos, Muriel
Tetrahedron Letters, 2009 , vol. 50, # 41 p. 5729 - 5732
反应条件
sulfuric acid; nitric acid
T=5 - 10°C; 1 h;
参考文献
Astrat'ev; Dashko; Mershin; Stepanov; Urazgil'deev
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 5 p. 729 - 733
