2-甲基-4,6-二羟基嘧啶合成路线 （共 21 条）
反应条件
1: KOCN
2: POCl3, PhNMe2
3: NH3, EtOH
4: 90 percent / methanol / Ambient temperature
View Scheme
参考文献
Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389
反应条件
1: KOCN
2: POCl3, PhNMe2
View Scheme
参考文献
Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389
反应条件
1: KOCN
2: POCl3, PhNMe2
3: NH3, EtOH
View Scheme
参考文献
Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389
反应条件
1: KOCN
2: POCl3, PhNMe2
3: liquid NH3
View Scheme
参考文献
Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389
反应条件
1: 85 percent / HNO3 / 1.5 h / 0 - 20 °C
2: 90 percent / POCl3, diethylaniline / 2 h / Heating
View Scheme
参考文献
Beck, James P.; Arvanitis, Argyrios G.; Curry, Matt A.; Rescinito, Joseph T.; Fitzgerald, Larry W.; Gilligan, Paul J.; Zaczek, Robert; Trainor, George L.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 967 - 972
反应条件
1: 87 percent / aq. Na2CO3 / 40 °C
2: 69 percent / dimethylformamide / Heating
3: 81 percent / Zn / acetic acid / 2 h / Heating
View Scheme
参考文献
Habib, Nargues Samuel; Kappe, Thomas
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 385 - 388
反应条件
triethylamine in tetrahydrofuran; toluene
T=20°C;
参考文献
Lee, Jae In
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 5 p. 1765 - 1768
反应条件
nitric acid
T=0 - 20°C; 1.5 h;
参考文献
Beck, James P.; Arvanitis, Argyrios G.; Curry, Matt A.; Rescinito, Joseph T.; Fitzgerald, Larry W.; Gilligan, Paul J.; Zaczek, Robert; Trainor, George L.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 967 - 972
反应条件
sulfuric acid; nitric acid
T=15 - 30°C; 18 h; Time;
参考文献
Latypov, Nikolaj V.; Johansson, Martin; Holmgren, Erik; Sizova, Ekaterina V.; Sizov, Vladimir V.; Bellamy, Anthony J.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 56 - 59
参考文献
DuPont Pharmaceuticals Company
Patent: US6342503 B1, 2002 ;
Location in patent: Example 101 ;
US 6342503 B1
