2-苯并噻吩-1(3H)-酮合成路线 （共 20 条）
反应条件
PPE
15 h; Ambient temperature;
参考文献
Vegh; Morel; Decroix; Zalupsky
Synthetic Communications, 1992 , vol. 22, # 14 p. 2057 - 2061
反应条件
1: 96 percent / NaBH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
2: 74 percent / 57percent aq. HI / acetic acid / 1 h / 125 °C
View Scheme
参考文献
Polec, Iwona; Lutsen, Laurence; Vanderzande, Dirk; Gelan, Jan
European Journal of Organic Chemistry, 2002 , # 6 p. 1033 - 1036
反应条件
1: 90 percent / acetone / 10 h / Heating
2: 87 percent / 2N KOH / H2O; methanol / 1 h / Heating
3: 90 percent / PPE / 15 h / Ambient temperature
View Scheme
参考文献
Vegh; Morel; Decroix; Zalupsky
Synthetic Communications, 1992 , vol. 22, # 14 p. 2057 - 2061
反应条件
1: 87 percent / 2N KOH / H2O; methanol / 1 h / Heating
2: 90 percent / PPE / 15 h / Ambient temperature
View Scheme
参考文献
Vegh; Morel; Decroix; Zalupsky
Synthetic Communications, 1992 , vol. 22, # 14 p. 2057 - 2061
反应条件
imidazole buffer in water
T=40°C; μ = 1.0 (with KCl);
参考文献
McDonald, Robert S.; Patterson, Patricia; Rodwell, June; Whalley, Ann
Canadian Journal of Chemistry, 1992 , vol. 70, # 1 p. 62 - 67
反应条件
1: alcohol
2: fuming hydrochloric acid / 180 °C / im Druckrohr
View Scheme
参考文献
Day; Gabriel
Chemische Berichte, 1890 , vol. 23, p. 2480
反应条件
sodium hydroxide
Behandeln mit Salzsaeure; anschliessend Behandeln der entstandenen 2-Mercaptomethyl-benzoesaeure mit Wasser;
参考文献
Day; Gabriel
Chemische Berichte, 1890 , vol. 23, p. 2480
反应条件
hydrogenchloride
T=40°C; ionic strength=1.0 with KCl; var. pH; other benzamide educt; ΔH(excit.), ΔS(exscit.);; KineticsMechanismThermodynamic data;
参考文献
McDonald, Robert S.; Patterson, Patricia; Stevens-Whalley, Ann
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1846 - 1852
参考文献
Prey; Kondler
Monatshefte fuer Chemie, 1958 , vol. 89, p. 505,507
反应条件
1: N-bromosuccinimide, α,α'-azobisisobutyronitrile / CCl4 / 1 h / Heating
2: benzene / 24 h / 90 - 95 °C
3: 49 percent / triethylamine / CH2Cl2 / 2 h
4: 32 percent / N-bromosuccinimide, α,α'-azobisisobutyronitrile / CCl4 / 20 h / Heating
View Scheme
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2698 - 2707
