4(1H)-嘧啶酮,6-羟基-2,5-二甲基-合成路线 （共 5 条）
反应条件
1: 1-Imino-ethanamine hydrochloride With sodium methylate in methanol T=0 - 20°C; 0.333333 h; 2: methyl malonic acid diethylester in methanol 3 h; 3: With acetic acid in water pH=4 - 5;
参考文献
Ruxer, Jean-Marie; Lefrancois, Jean Michel; Heckmann, Bertrand
Patent: US2006/52398 A1, 2006 ;
Location in patent: Page/Page column 74-75 ;
反应条件
1: With sodium in ethanol 2.5 h; Heating / reflux; 2: With hydrogenchloride in water T=4°C; 1 h;
参考文献
WO2005/95357 A2, ;
Page/Page column 173 ;
WO 2005/095357 A2
反应条件
1: 1-Imino-ethanamine hydrochloride With sodium methylate in methanol T=0°C; 2: methylmalonic acid dimethyl ester in methanol T=75°C; 4 h; 3: With hydrogenchloride in water
参考文献
WO2011/150156 A2, ;
Page/Page column 124 ;
WO 2011/150156 A2
反应条件
1.1: trichlorophosphate / 100 °C 1.2: pH 8 - 9 2.1: ammonium hydroxide / ethanol / 8 h / 80 °C View Scheme
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
WO 2011/150156 A2
反应条件
trichlorophosphate 8 h; Heating / reflux;
参考文献
US2006/52398 A1, ;
Page/Page column 75 ;
