1.1: potassium carbonate / acetonitrile / |Reflux
2.1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
3.1: potassium carbonate / acetonitrile / 60 h / |Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
5.2: 20 °C
6.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
1: 2,5-dihydroxy-benzaldehyde With 1H-imidazole in dichloromethane
2: tert-butyldimethylsilyl chloride in dichloromethane
T=20°C;
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
Location in patent: Page/Page column 21 ;
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
