反应条件
1: 1H-imidazole / dichloromethane / 3.67 h / 10 - 15 °C 2: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene; acetic acid / dichloromethane / 13 - 18 °C / Inert atmosphere 3: tetrahydrofuran; toluene / 5.42 h / 20 - 35 °C 4: hydrogenchloride; water / methanol / 7 h / 40 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; BENNETT, Frank; HUANG, Yuhua; WANG, Lingyan; BOGEN, Stephane, L.; KEREKES, Angela, D.; GIRIJAVALLABHAN, Vinay M.; BUTORA, Gabor; TRUONG, Quang; DAVIES, Ian; WEBER, Anne E.
Patent: WO2014/78463 A1, 2014 ;