叔丁氧羰基-3-(4-噻唑基)-L-丙氨酸合成路线 （共 20 条）
反应条件
1: 84 percent / tetrahydrofuran / 4 h / Ambient temperature 2: 89 percent / 6N NaOH / ethanol / Ambient temperature 3: 1.) 1N KCl, 1N NaOH, subtilisin, 2.) 6N HCl / 1.) water, 1 h, 2.) water, reflux, 4 h 4: NaHCO3, 3N NaOH / tetrahydrofuran / pH 10 View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
1: 89 percent / 6N NaOH / ethanol / Ambient temperature 2: 1.) 1N KCl, 1N NaOH, subtilisin, 2.) 6N HCl / 1.) water, 1 h, 2.) water, reflux, 4 h 3: NaHCO3, 3N NaOH / tetrahydrofuran / pH 10 View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
1: 1.) 1N KCl, 1N NaOH, subtilisin, 2.) 6N HCl / 1.) water, 1 h, 2.) water, reflux, 4 h 2: NaHCO3, 3N NaOH / tetrahydrofuran / pH 10 View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
1: 53 percent / tetrahydrofuran / 120 h / Ambient temperature 2: 1a.) 1N aq. NaOH, 1b.) 1N HCl, 2.) HBr, HOAc / 1a.) THF, RT, 30 min, 2.) RT, 2.5 h 3: NaHCO3, NaOH / tetrahydrofuran; H2O / 24 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
1: 1a.) 1N aq. NaOH, 1b.) 1N HCl, 2.) HBr, HOAc / 1a.) THF, RT, 30 min, 2.) RT, 2.5 h 2: NaHCO3, NaOH / tetrahydrofuran; H2O / 24 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
1: 89 percent / 1N HCl / CH2Cl2; diethyl ether / 1 h / Ambient temperature 2: 53 percent / tetrahydrofuran / 120 h / Ambient temperature 3: 1a.) 1N aq. NaOH, 1b.) 1N HCl, 2.) HBr, HOAc / 1a.) THF, RT, 30 min, 2.) RT, 2.5 h 4: NaHCO3, NaOH / tetrahydrofuran; H2O / 24 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
sodium hydroxide; sodium hydrogencarbonate in tetrahydrofuran pH 10; Yield given;
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
sodium hydroxide; sodium hydrogencarbonate in tetrahydrofuran; water 24 h; Ambient temperature; Yield given;
参考文献
Synthetic Communications, , vol. 20, # 22 p. 3507 - 3517
反应条件
Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 1 p. 103 - 109
反应条件
1: 91 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C 2: 4N HCl / dioxane / 0.5 h / Ambient temperature 3: 71 percent / DEPC, triethylamine / tetrahydrofuran / 8 h / 0 °C View Scheme
参考文献
Nishi; Saito; Nagahori; Kataoka; Morisawa; Yabe; Sakurai; Higashida; Shoji; Matsushita; Iijima; Ohizumi; Koike
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 103 - 109
