3-甲基-5-三氯甲基-1,2,4-噁二唑合成路线 （共 5 条）
反应条件
1: With mercury T=120 - 130°C; 3 h; 2: With sodium hydrogencarbonate in water
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281398 A1, 2013 ;
Location in patent: Paragraph 0501; 0502 ;
反应条件
triethylamine in toluene 24 h; ultrasound;
参考文献
Bolton, Richard E.; Coote, Steven J.; Finch, Harry; Lowdon, Andrew; Pegg, Neil; Vinader, M. Victoria
Tetrahedron Letters, 1995 , vol. 36, # 25 p. 4471 - 4474
反应条件
ammonia in methanol T=17 - 25°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/99326 A1, 2007 ;
Location in patent: Page/Page column 105 ;
WO 2007/099326 A1
反应条件
potassium hydroxide in methanol; ethanol
参考文献
Moussebois,C.; Eloy,F.
Helvetica Chimica Acta, 1964 , vol. 47, p. 838 - 848
反应条件
para-thiocresol in methanol Ambient temperature; Yields of byproduct given;
参考文献
Gazzetta Chimica Italiana, , vol. 118, # 8 p. 609 - 610
