3-(3-噻吩基)丙烯酸合成路线 （共 14 条）
反应条件
1: With triethylamine in acetone
Cooling with ice;
2: With sodium azide in water; acetone
1 h; Cooling with ice;
3: With tributyl-amine; diphenylamine
T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
1.1: 94 percent / ammonium formate; Pd-C / propan-2-ol / 6 h / 90 °C
2.1: 54 percent / phosphorus pentoxide; methanesulfonic acid / 0.67 h / 20 °C
3.1: 81 percent / LDA / tetrahydrofuran / 12 h / 20 °C
4.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C
4.2: 65 percent / HCl / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Bonini, Bianca Flavia; Capito, Elena; Comes-Franchini, Mauro; Ricci, Alfredo; Bottoni, Andrea; Bernardi, Fernando; Miscione, Gian Pietro; Giordano, Laurent; Cowley, Andrew R.
European Journal of Organic Chemistry, 2004 , # 21 p. 4442 - 4451
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform
Heating; Yield given;
参考文献
Li, Lingjun; Degardin, Melissa; Lavergne, Thomas; Malyshev, Denis A.; Dhami, Kirandeep; Ordoukhanian, Phillip; Romesberg, Floyd E.
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 826 - 829
反应条件
pyridine; thionyl chloride in chlorobenzene
T=140°C; 18 h;
参考文献
DoganKoruznjak, Jasna; Slade, Neda; Zamola, Branimir; Pavelic, Kresimir; Karminski-Zamola, Grace
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 5 p. 656 - 660
