2-氯-2',3'-二去氢-2',3'-二脱氧腺苷合成路线 （共 7 条）
反应条件
silica gel in benzene 96 h; Ambient temperature;
参考文献
Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
反应条件
1: imidazole / pyridine / 20 °C 2: acetonitrile / 20 °C 3: 1,3-dimethyl-2-phenyl-1,3-diazaphospholidine / tetrahydrofuran / 20 °C 4: TBAF on silica gel / tetrahydrofuran / 20 °C View Scheme
参考文献
Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
反应条件
1: 80 percent / acetonitrile / Ambient temperature 2: 60 percent / 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine / tetrahydrofuran / 24 h / Ambient temperature 3: 69 percent / silica gel / benzene / 96 h / Ambient temperature View Scheme
参考文献
Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
反应条件
1: 60 percent / 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine / tetrahydrofuran / 24 h / Ambient temperature 2: 69 percent / silica gel / benzene / 96 h / Ambient temperature View Scheme
参考文献
Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
反应条件
1: SnCl4 / acetonitrile / 20 °C 2: NH3 / methanol / 20 °C 3: imidazole / pyridine / 20 °C 4: acetonitrile / 20 °C 5: 1,3-dimethyl-2-phenyl-1,3-diazaphospholidine / tetrahydrofuran / 20 °C 6: TBAF on silica gel / tetrahydrofuran / 20 °C View Scheme
参考文献
Lioux, Thierry; Gosselin, Gilles; Mathe, Christophe
European Journal of Organic Chemistry, 2003 , # 20 p. 3997 - 4002
反应条件
1: NH3 / methanol / 20 °C 2: imidazole / pyridine / 20 °C 3: acetonitrile / 20 °C 4: 1,3-dimethyl-2-phenyl-1,3-diazaphospholidine / tetrahydrofuran / 20 °C 5: TBAF on silica gel / tetrahydrofuran / 20 °C View Scheme
参考文献
Lioux, Thierry; Gosselin, Gilles; Mathe, Christophe
European Journal of Organic Chemistry, 2003 , # 20 p. 3997 - 4002
反应条件
1: SnCl4 / acetonitrile / 20 °C 2: NH3 / methanol / 20 °C 3: imidazole / pyridine / 20 °C 4: acetonitrile / 20 °C 5: 1,3-dimethyl-2-phenyl-1,3-diazaphospholidine / tetrahydrofuran / 20 °C 6: TBAF on silica gel / tetrahydrofuran / 20 °C View Scheme
参考文献
Lioux, Thierry; Gosselin, Gilles; Mathe, Christophe
European Journal of Organic Chemistry, 2003 , # 20 p. 3997 - 4002
