反应条件
Multi-step reaction with 6 steps 1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C2: pyridine / dichloromethane / 20 °C3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / |Cooling with ice4: N-bromosuccinmide / N,N-dimethyl acetamide / 0.25 h / 20 °C5: N,N-dimethyl acetamide / 20 - 60 °C6: N,N-dimethyl acetamide / 60 - 80 °C
参考文献
Rheault, Tara R.; Stellwagen, John C.; Adjabeng, George M.; Hornberger, Keith R.; Petrov, Kimberly G.; Waterson, Alex G.; Dickerson, Scott H.; Mook, Robert A.; Laquerre, Sylvie G.; King, Alastair J.; Rossanese, Olivia W.; Arnone, Marc R.; Smitheman, Kimberly N.; Kane-Carson, Laurie S.; Han, Chao; Moorthy, Ganesh S.; Moss, Katherine G.; Uehling, David E. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 3 p. 358 - 362