1: (3R)-3-hydroxy-1-azabicyclo[2.2.2]octane With sodium hydride in tetrahydrofuran 0.75 h; Reflux; 2: (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride in tetrahydrofuran 1.5 h; Reflux;