3,4-二氢异喹啉-1(2H)-酮合成路线 （共 71 条）
反应条件
nitric acid T=0°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
参考文献
Bamberger; Dieckmann
Chemische Berichte, 1893 , vol. 26, p. 1211
反应条件
tetraphosphorus decasulfide in dichloromethane
5 h; Inert atmosphereReflux;
参考文献
Cho, Dongho; Ahn, Jiyoung; De Castro, Kathlia A.; Ahn, Hyunseok; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 30 p. 5583 - 5588
反应条件
1: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
2: 93 percent / H2 / 10percent Pd/C / methanol
3: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione in toluene
T=130°C; 24 h; Schlenk techniqueInert atmosphereSealed tube;
参考文献
Ruiz Espelt, Laura; Wiensch, Eric M.; Yoon, Tehshik P.
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4107 - 4114
反应条件
1: sulfuric acid; nitric acid / 2 h / |Cooling with ice
2: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr
3: SnCl2·2H2O; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
反应条件
ruthenium(IV) oxide; sodium periodate in ethyl acetate
8 h; Ambient temperature;
参考文献
Yoshifuji; Arakawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 12 p. 3380 - 3381
反应条件
1: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
2: 93 percent / H2 / 10percent Pd/C / methanol
3: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
4: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
2: 93 percent / H2 / 10percent Pd/C / methanol
3: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
4: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
5: 84 percent / NaOAc / H2O; acetic acid / 1 h / 50 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
2: 64 percent / conc. HCl / 24 h / 150 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
