4-溴-1-甲基-1H-吡咯-2-羧酸甲酯合成路线 （共 6 条）
反应条件
sodium hydride in methanol; mineral oil 0.5 h; Reflux;
参考文献
SPIROGEN SÀRL; UCL BUSINESS PLC; HOWARD, Philip Wilson; THURSTON, David; RAHMAN, Khondaker Mirazur
Patent: WO2013/164593 A1, 2013 ;
Location in patent: Page/Page column 42 ;
反应条件
sodium methylate 0.5 h; Heating / reflux;
参考文献
Rahman, Khondaker M.; Jackson, Paul J. M.; James, Colin H.; Basu, B. Piku; Hartley, John A.; De La Fuente, Maria; Schatzlein, Andreas; Robson, Mathew; Pedley, R. Barbara; Pepper, Chris; Fox, Keith R.; Howard, Philip W.; Thurston, David E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2911 - 2935
反应条件
1: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 2: 93 percent / methanol / 1 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 91 percent / CH2Cl2 / 24 h 2: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 3: 93 percent / methanol / 1 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C 2: 94 percent / LiOH / tetrahydrofuran; methanol / 9 h / 60 °C View Scheme
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane T=110°C; 48 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
