6-溴-2-氯噻唑并[5,4-b]吡啶合成路线 （共 3 条）
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile T=0 - 20°C;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; ROeHN, Ulrike; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BERGER, Markus; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNIEDER, Damian; DYRKS, Thomas; THIELE, Andrea; MOeNNING, Ursula; BOeMER, Ulf
Patent: WO2012/7510 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1.1: benzoyl chloride / acetone / 0.25 h / Reflux 1.2: 1.5 h / 40 °C / Reflux 1.3: 2 h / 60 °C 2.1: caesium carbonate; copper(l) iodide; DL-proline / dimethyl sulfoxide / 2 h 2.2: pH 8 3.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0 - 20 °C View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; ROeHN, Ulrike; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BERGER, Markus; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNIEDER, Damian; DYRKS, Thomas; THIELE, Andrea; MOeNNING, Ursula; BOeMER, Ulf
Patent: WO2012/7510 A1, 2012 ;
反应条件
1.1: caesium carbonate; copper(l) iodide; DL-proline / dimethyl sulfoxide / 2 h 1.2: pH 8 2.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0 - 20 °C View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; ROeHN, Ulrike; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BERGER, Markus; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNIEDER, Damian; DYRKS, Thomas; THIELE, Andrea; MOeNNING, Ursula; BOeMER, Ulf
Patent: WO2012/7510 A1, 2012 ;
