6-溴-2,2-二甲基-2H-吡啶并[3,2-b][1,4]噁嗪-3(4h)-酮合成路线 （共 5 条）
反应条件
1: With iron; acetic acid T=90°C; 2 h; 2: With sodium hydrogencarbonate in water
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
Location in patent: Page/Page column 100 ;
WO 2011/059839 A1
反应条件
hydrogenchloride; sodium hydrogencarbonate; tin(ll) chloride in methanol; water
参考文献
Zeifman, Alexey A.; Titov, Ilya Yu.; Svitanko, Igor V.; Rakitina, Tatiana V.; Lipkin, Aleksey V.; Stroylov, Viktor S.; Stroganov, Oleg V.; Novikov, Fedor N.; Chilov, Ghermes G.
Mendeleev Communications, 2012 , vol. 22, # 2 p. 73 - 74
反应条件
1.1: sodium methylate; bromine / methanol / 0.5 h / 0 °C 1.2: 0.17 h / 0 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 3.1: acetic acid; iron / 2 h / 90 °C View Scheme
参考文献
Zeifman, Alexey A.; Titov, Ilya Yu.; Svitanko, Igor V.; Rakitina, Tatiana V.; Lipkin, Aleksey V.; Stroylov, Viktor S.; Stroganov, Oleg V.; Novikov, Fedor N.; Chilov, Ghermes G.
Mendeleev Communications, 2012 , vol. 22, # 2 p. 73 - 74
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: acetic acid; iron / 2 h / 90 °C View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
WO 2011/059839 A1
反应条件
1: bromine; acetic acid 2: hydrogenchloride; sodium hydrogencarbonate; tin(ll) chloride / methanol; water View Scheme
参考文献
Zeifman, Alexey A.; Titov, Ilya Yu.; Svitanko, Igor V.; Rakitina, Tatiana V.; Lipkin, Aleksey V.; Stroylov, Viktor S.; Stroganov, Oleg V.; Novikov, Fedor N.; Chilov, Ghermes G.
Mendeleev Communications, 2012 , vol. 22, # 2 p. 73 - 74
