N-[2-(5-溴-1H-吲哚-3-基)乙基]乙酰胺合成路线 （共 8 条）
反应条件
acetic acid in water; ethyl acetate T=70°C; 0.5 h; Inert atmosphere;
参考文献
Boyd, Emily M.; Sperry, Jonathan
Tetrahedron Letters, 2012 , vol. 53, # 28 p. 3623 - 3626
反应条件
hydrogen bromide in methanol; water T=20°C; Bromination; 20 h;
参考文献
Hasegawa, Masakazu; Yamada, Koji; Nagahama, Yoshiyuki; Somei, Masanori
Heterocycles, 1999 , vol. 51, # 12 p. 2815 - 2821
反应条件
hydrogen bromide in methanol; water T=20°C; Bromination; 55 h;
参考文献
Hasegawa, Masakazu; Yamada, Koji; Nagahama, Yoshiyuki; Somei, Masanori
Heterocycles, 1999 , vol. 51, # 12 p. 2815 - 2821
反应条件
TEA in tetrahydrofuran 6 h; Ambient temperature; Yield given;
参考文献
Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Carey, Aedin; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Nonno, Romolo; Lucini, Valeria; Pannacci, Marilou; Michaylov Stankov, Bojidar; Fraschini, Franco
Medicinal Chemistry Research, 1998 , vol. 8, # 9 p. 487 - 498
反应条件
1: 50 percent / trifluoroacetic acid / 0.5 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 5 h / 20 °C 3: triethylamine / tetrahydrofuran / 20 °C View Scheme
参考文献
Mor, Marco; Rivara, Silvia; Silva, Claudia; Bordi, Fabrizio; Plazzi, Pier Vincenzo; Spadoni, Gilberto; Diamantini, Giuseppe; Balsamini, Cesarino; Tarzia, Giorgio; Fraschini, Franco; Lucini, Valeria; Nonno, Romolo; Stankov, Bojidar Michaylov
Journal of Medicinal Chemistry, 1998 , vol. 41, # 20 p. 3831 - 3844
反应条件
hydrogen bromide in water; acetonitrile T=80°C; Bromination; 3 h;
参考文献
Hasegawa, Masakazu; Yamada, Koji; Nagahama, Yoshiyuki; Somei, Masanori
Heterocycles, 1999 , vol. 51, # 12 p. 2815 - 2821
反应条件
1: 2-(5-bromo-1H-indol-3-yl)ethylamine With triethylamine in dichloromethane T=20°C; 0.166667 h; Inert atmosphere; 2: acetyl chloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Lozano, Oscar; Blessley, George; Martinez Del Campo, Teresa; Thompson, Amber L.; Giuffredi, Guy T.; Bettati, Michela; Walker, Matthew; Borman, Richard; Gouverneur, Veronique
Angewandte Chemie - International Edition, 2011 , vol. 50, # 35 p. 8105 - 8109
反应条件
1: 72 percent / 4-N,N-dimethylaminopyridine 2: 38 percent / HBr / H2O; methanol / 55 h / 20 °C View Scheme
参考文献
Hasegawa, Masakazu; Yamada, Koji; Nagahama, Yoshiyuki; Somei, Masanori
Heterocycles, 1999 , vol. 51, # 12 p. 2815 - 2821
