4-氯-5-碘-1-(苯基磺酰基)-1H-吡咯并[2,3-b]吡啶合成路线 （共 5 条）
反应条件
1: 4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.333333 h; 2: benzenesulfonyl chloride in N,N-dimethyl-formamide; mineral oil T=20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/140320 A1, 2009 ;
Location in patent: Page/Page column 98-99 ;
WO 2009/140320 A1
反应条件
1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C 1.2: 0.75 h / -78 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 3.2: 2 h / 20 °C View Scheme
参考文献
VERNALIS (RandD) LIMITED; STOKES, Stephen; GRAHAM, Christoper John; RAY, Stuart Christopher; STEFANIAK, Emma Jayne
Patent: WO2013/114113 A1, 2013 ;
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C 2.2: 2 h / 20 °C View Scheme
参考文献
VERNALIS (RandD) LIMITED; STOKES, Stephen; GRAHAM, Christoper John; RAY, Stuart Christopher; STEFANIAK, Emma Jayne
Patent: WO2013/114113 A1, 2013 ;
反应条件
1: copper(l) iodide / N,N-dimethyl-formamide / 2.5 h / 100 °C 2: lithium hydroxide hydrate / water; tetrahydrofuran / 64 h / 20 °C View Scheme
参考文献
VERNALIS (RandD) LIMITED; STOKES, Stephen; GRAHAM, Christoper John; RAY, Stuart Christopher; STEFANIAK, Emma Jayne
Patent: WO2013/114113 A1, 2013 ;
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/140320 A1, 2009 ;
Location in patent: Page/Page column 99 ;
WO 2009/140320 A1
