Hydrolysis;

<b>Multi-step reaction with 4 steps<br /> </b>1: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature<br />2: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h<br />3: 24 percent / LiAlH₄ / tetrahydrofuran / 4 h / -78 &deg;C<br />4: 88 percent / PPh₃, CBr₄, iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h<br />2: 24 percent / LiAlH₄ / tetrahydrofuran / 4 h / -78 &deg;C<br />3: 88 percent / PPh₃, CBr₄, iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: CHCl₃ / 2 h / Heating<br />2: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature<br />3: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature<br />4: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h<br />5: 24 percent / LiAlH₄ / tetrahydrofuran / 4 h / -78 &deg;C<br />6: 88 percent / PPh₃, CBr₄, iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature<br /> <br /> &nbsp;