顺式-4-氨基甲基-1-环己烷羧酸合成路线 （共 9 条）
反应条件
sodium hydroxide; magnesium oxide in 1,4-dioxane; CH3 COOC2 H5; water
参考文献
ELF Sanofi
Patent: US5506258 A1, 1996 ;
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Sankyo Company, Limited
Patent: US5843973 A1, 1998 ;
反应条件
potassium hydrogencarbonate in 1,4-dioxane 18 h;
参考文献
FERRING B.V.
Patent: WO2006/21213 A2, 2006 ;
Location in patent: Page/Page column 40-41 ;
WO 2006/021213 A2
反应条件
triethylamine in water; ethyl acetate
参考文献
Okamoto, Shosuke; SHOWA DENKO KABUSHIKI KAISHA
Patent: EP284632 A1, 1988 ;
反应条件
1: With sodium carbonate in 1,4-dioxane; water T=20°C; 2.5 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
Revotar Biopharmaceuticals AG
Patent: EP1577289 A1, 2005 ;
Location in patent: Page/Page column 23 ;
反应条件
1: With sodium carbonate in 1,4-dioxane; water 2: With hydrogenchloride in 1,4-dioxane; water pH=3;
参考文献
Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 17; 18 ;
反应条件
1: 4-(aminomethyl)cyclohexanecarboxylic acid in methanol
T=5°C; 0.166667 h; Inert atmosphereLarge scale;
2: With thionyl chloride in methanol
T=10 - 25°C; 3.5 h; Inert atmosphereLarge scale;
3: tert-butyl methyl ether T=-5 - 30°C; 1.45 h; Large scale; TemperatureTimeReagent/catalyst;
参考文献
Betti, Matteo; Genesio, Eva; Panico, Alessandro; Sanna Coccone, Salvatore; Wiedenau, Paul
Organic Process Research and Development, 2013 , vol. 17, # 8 p. 1042 - 1051
反应条件
chloro-trimethyl-silane
T=20°C; 12 h;
参考文献
Li, Jiabo; Sha, Yaowu
Molecules, 2008 , vol. 13, # 5 p. 1111 - 1119
反应条件
Stage #1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3 h; Stage #2: With water in tetrahydrofuran T=0°C; Show Experimental Procedure
参考文献
CHROMA THERAPEUTICS LTD. Patent: WO2008/53131 A1, 2008 ; Location in patent: Page/Page column 72-73 ;
