反应条件
1.1: iron(II) sulfate; nitrobenzene; sulfuric acid / 5 h / |Inert atmosphere; |Reflux 2.1: thionyl chloride / 2 h / 0 °C / |Inert atmosphere; |Reflux 3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 3.2: -78 - 20 °C / |Inert atmosphere 4.1: lithium hydroxide hydrate / methanol; water / 4 h / 65 °C / |Inert atmosphere View Scheme
参考文献
Cui, J. Jean; Shen, Hong; Tran-Dube, Michelle; Nambu, Mitchell; McTigue, Michele; Grodsky, Neil; Ryan, Kevin; Yamazaki, Shinji; Aguirre, Shirley; Parker, Max; Li, Qiuhua; Zou, Helen; Christensen, James
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6651 - 6665