1: With acetic acid in dichloromethane; water T=20 - 30°C; pH=4.0 - 4.5; 2: With sulfuric acid; water T=5 - 10°C; 1 h; 3: With sodium hydroxide in water; ethyl acetate; tert-butyl alcohol T=10 - 30°C; pH=3.5 - 4; Product distribution / selectivity;

1.1: sulfuric acid; water / 5 - 10 °C 2.1: ethyl acetate / 25 - 30 °C 3.1: acetic acid / dichloromethane; water / 25 - 30 °C 3.2: 25 - 30 °C View Scheme

1: sodium methylate / methanol; N,N-dimethyl-formamide / 26 h / 25 - 45 °C 2: sulfuric acid; water / 2.5 h / 0 - 10 °C / Inert atmosphere View Scheme